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Index > Protein center > SLC39A4(Gene name) > Human
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  • SLC39A4 (Gene name),
  • Zinc transporter ZIP4 (Protein name ),  S39A4_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    SLC39A4(ZIP4);
    Protein name:
    Zinc transporter ZIP4;
    Alternative:
    Zrt- and Irt-like protein 4(ZIP-4);Solute carrier family 39 member 4;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Plays an important role in cellular zinc homeostasis as a zinc transporter. Regulated in response to zinc availability.
    Subcellular Location:
    Cell membrane Multi-pass membrane protein Recycling endosome membrane Multi-pass membrane protein Colocalized with TFRC in the recycling endosomes. Cycles between endosomal compartments and the plasma membrane in response to zinc availability.
    Protein Attributes:
    Sequence length:
    647
    Sequence:
    50:
    MASLVSLELG | LLLAVLVVTA | TASPPAGLLS | LLTSGQGALD | QEALGGLLNT | 
    100:
    LADRVHCANG | PCGKCLSVED | ALGLGEPEGS | GLPPGPVLEA | RYVARLSAAA | 
    150:
    VLYLSNPEGT | CEDARAGLWA | SHADHLLALL | ESPKALTPGL | SWLLQRMQAR | 
    200:
    AAGQTPKTAC | VDIPQLLEEA | VGAGAPGSAG | GVLAALLDHV | RSGSCFHALP | 
    250:
    SPQYFVDFVF | QQHSSEVPMT | LAELSALMQR | LGVGREAHSD | HSHRHRGASS | 
    300:
    RDPVPLISSS | NSSSVWDTVC | LSARDVMAAY | GLSEQAGVTP | EAWAQLSPAL | 
    350:
    LQQQLSGACT | SQSRPPVQDQ | LSQSERYLYG | SLATLLICLC | AVFGLLLLTC | 
    400:
    TGCRGVTHYI | LQTFLSLAVG | ALTGDAVLHL | TPKVLGLHTH | SEEGLSPQPT | 
    450:
    WRLLAMLAGL | YAFFLFENLF | NLLLPRDPED | LEDGPCGHSS | HSHGGHSHGV | 
    500:
    SLQLAPSELR | QPKPPHEGSR | ADLVAEESPE | LLNPEPRRLS | PELRLLPYMI | 
    550:
    TLGDAVHNFA | DGLAVGAAFA | SSWKTGLATS | LAVFCHELPH | ELGDFAALLH | 
    600:
    AGLSVRQALL | LNLASALTAF | AGLYVALAVG | VSEESEAWIL | AVATGLFLYV | 
    647:
    ALCDMLPAML | KVRDPRPWLL | FLLHNVGLLG | GWTVLLLLSL | YEDDITF
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    Pfam:
    MIM:
    UniGene:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Zinc transporter ZIP4
    Cat.:
    E11045h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Zinc transporter ZIP4
    Cat.:
    E11045m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human Zinc transporter ZIP4
    Cat.:
    E11045r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human Zinc transporter ZIP4
    Cat.:
    E11045b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Zinc transporter ZIP4
    Cat.:
    U11045m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Zinc transporter ZIP4
    Cat.:
    U11045b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Zinc transporter ZIP4
    Cat.:
    U11045r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Zinc transporter ZIP4
    Cat.:
    U11045h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Zinc transporter ZIP4
    Cat.:
    P11045Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Zinc transporter ZIP4
    Polyclonal Antibody for Human Zinc transporter ZIP4
    Cat.:
    P11045Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Zinc transporter ZIP4
    Cat.:
    P11045Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Zinc transporter ZIP4
    Monoclonal Antibody for Human Zinc transporter ZIP4
    Monoclonal Antibody for Human Zinc transporter ZIP4
    Monoclonal Antibody for Human Zinc transporter ZIP4
    Protein for Human Zinc transporter ZIP4
    Protein for Human Zinc transporter ZIP4
    Protein for Human Zinc transporter ZIP4
    Protein for Human Zinc transporter ZIP4

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    References
    1. 1.
      "Identification of SLC39A4, a gene involved in acrodermatitis enteropathica."
      Kuery S. , Dreno B. , Bezieau S. , Giraudet S. , Kharfi M. , Kamoun R. , Moisan J.-P.
      Nat. Genet.31:239-240(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);TISSUE SPECIFICITY;VARIANTS AEZ LEU-200; ARG-374 AND ARG-526
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2);VARIANTS THR-58; THR-114; AEZ TYR-309 AND ALA-357
    3. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANTS THR-58 AND THR-114
      tissue: Lung.
      tissue: Ovary.
    4. 5.
      "A novel member of a zinc transporter family is defective in acrodermatitis enteropathica."
      Wang K. , Zhou B. , Kuo Y.-M. , Zemansky J. , Gitschier J.
      Am. J. Hum. Genet.71:66-73(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;VARIANTS THR-58; THR-114 AND ALA-357;VARIANTS AEZ LEU-84; LYS-106; TRP-251; TYR-309; ASP-330; PRO-372; PRO-410 AND ARG-630
    5. 6.
      "Zn2+-stimulated endocytosis of the mZIP4 zinc transporter regulates its location at the plasma membrane."
      Kim B.-E. , Wang F. , Dufner-Beattie J. , Andrews G.K. , Eide D.J. , Petris M.J.
      J. Biol. Chem.279:4523-4530(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    6. 7.
      "Novel SLC39A4 mutations in acrodermatitis enteropathica."
      Nakano A. , Nakano H. , Nomura K. , Toyomaki Y. , Hanada K.
      J. Invest. Dermatol.120:963-966(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS AEZ CYS-95 AND HIS-303
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